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Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation AbstractStimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate invading pathogens and serves as a self-limiting mechanism of STING-induced interferon (IFN) responses. Thus, the mechanisms that ensure the bene fi cial effects of STING activation are of particular importance. Herein, we show that myristic acid, a type of long-chain saturated fatty...
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MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis Chronic inflammation is the primary cause of gastric cancer (GC). NLRP3, as an important inflammasome component, has crucial roles in initiating inflammation. However, the potential roles of NLRP3 in GC is unknown.
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JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis This study investigated the role of histone demethylase Jumonji domain-containing protein 2B (JMJD2B) in promoting epithelial-mesenchymal transition (EMT) and underlying molecular mechanisms ...
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