韩冰，男，理学博士，中共党员

山东大学病原生物学系教授，博士研究生导师，学系副主任，山东大学齐鲁青年学者，北京市青年人才托举工程“青托人才”，阿尔伯特.爱因斯坦医学院客座助理教授。

教育及工作背景：

2021.03-至今：山东大学基础医学院病原生物学系，教授，博导，齐鲁青年学者，学系副主任

2020.03-至今：山东大学基础医学院病原生物学系，教授，博导，齐鲁青年学者

2017.8-2019.9：阿尔伯特.爱因斯坦医学院（Albert Einstein College of Medicine），病原生物学专业，博士后

2014.9-2016.9：国家公派中美联合培养博士研究生（西南大学-Yeshiva University）

2012.9-2013.9：中国科技大学访问学者

2011.9-2017.6：西南大学家蚕基因组生物学国家重点实验室，微生物学专业，博士

2007.9-2011.6：济宁学院，生物工程专业，学士

研究方向：

1.微孢子虫极管的蛋白组成、结构以及功能研究；

2.微孢子虫侵染过程中与宿主的互作机制研究；

3.弓形虫侵染过程中与宿主的互作机制研究；

4.疟原虫侵染机制研究以及药物筛选。

科研课题：

1.国家自然科学基金青年项目，32000106，脑炎微孢子虫与宿主线粒体VDAC蛋白的互作机制研究，2021/01-2023/12，24万元，在研，主持：

2.阿尔伯特.爱因斯坦医学院博士后基金：2018.06-2019.07，已结题，主持；

3.美国国立卫生研究院（NIH）RO1基金（Al124753）：2016.05-2021.04，已结题，主要完成人。

研究论文：

1. Bing Han, Guoqing Pan, Louis M. Weiss. Microsporidiosis in humans. Clinical Microbiology Reviews, 2021 Dec 15;34(4):e0001020. doi: 10.1128/CMR.00010-20. Epub 2021 Jun 30. PMID: 34190570; PMCID: PMC8404701.

2. Han B, Ma Y, Tu V, Tomita T, Mayoral J, Williams T, Horta A, Huang H, Weiss L M. Microsporidia Interact with Host Cell Mitochondria via Voltage-Dependent Anion Channels Using Sporoplasm Surface Protein 1 [J]. mBio, 2019, 10(4): e01944-01919.

3. Han B, Polonais V, Sugi T, Yakubu R, Takvorian P M, Cali A, Maier K, Long M, Levy M, Tanowitz H B. The role of microsporidian polar tube protein 4 (PTP4) in host cell infection [J]. PLoS pathogens, 2017, 13(4): e1006341.

4. Han B, Takvorian P M, Weiss L M. Invasion of Host Cells by Microsporidia [J]. Frontiers in Microbiology, 2020, 11(172): 1-16.

5. Takvorian, P.M.#, Han, B.#, Cali, A., Rice, W.J., Gunther, L., Macaluso, F. and Weiss, L.M. (2020), An Ultrastructural Study of the Extruded Polar Tube of Anncaliia algerae (Microsporidia). J. Eukaryot. Microbiol., 67: 28-44.

6. Han B, Moretto M, M. Weiss L. Encephalitozoon: Tissue Culture, Cryopreservation, and Murine Infection [J]. Current protocols in microbiology, 2019, 52(1): e72.

7. Han B, Weiss L M. Therapeutic targets for the treatment of microsporidiosis in humans [J]. Expert opinion on therapeutic targets, 2018, 22(11): 903-915.

8. Han B, Weiss L M. Microsporidia: Obligate intracellular pathogens within the fungal kingdom [J]. Microbiology Spectrum, 2017, 5(2):

9. Han B#, Zhou K#, Li Z, Sun B, Ni Q, Meng X, Pan G, Li C, Long M, Li T, Zhou C, Li W, Zhou Z. Characterization of the First Fungal Glycosyl Hydrolase Family 19 Chitinase (NbchiA) from Nosema bombycis (Nb) [J]. The Journal of eukaryotic microbiology, 2015,

10. Cui, L. L., Zhou, C. X., Han, B., Wang, S. S., Li, S. Y., Xie, S. C., & Zhou, D. H. (2021). Urine proteomics for profiling of mouse toxoplasmosis using liquid chromatography tandem mass spectrometry analysis. Parasites & vectors, 14(1), 211.

11. Wang, Y., Han, R., Xu, Z., Sun, X., Zhou, C., Han, B., He, S., & Cong, H. (2021). Upregulation of lncRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Microglia Apoptosis by Regulating Hoxb3. Frontiers in cellular neuroscience, 15, 648047.

12. Zhou, C. X., Gao, M., Han, B., Cong, H., Zhu, X. Q., & Zhou, H. Y. (2021). Quantitative Peptidomics of Mouse Brain After Infection With Cyst-Forming Toxoplasma gondii. Frontiers in immunology, 12, 681242.

13. Horta A L, Williams T, Han B, Ma Y, Menezes A P J, Tu V, Talvani A, Weiss L M, Huang H. Resolvin D1 Administration is Beneficial in Trypanosoma cruzi Infection [J]. Infection and immunity, 2020, IAI.00052-00020.

14. Tu V, Mayoral J, Yakubu R R, Tomita T, Sugi T, Han B, Williams T, Ma Y, Weiss L M. MAG2, a Toxoplasma gondii Bradyzoite Stage-Specific Cyst Matrix Protein [J]. mSphere, 2020, 5(1): e00100-00120.

15. Tu V, Mayoral J, Sugi T, Tomita T, Han B, Ma Y F, Weiss L M. Enrichment and Proteomic Characterization of the Cyst Wall from In Vitro Toxoplasma gondii Cysts [J]. mBio, 2019, 10(2): e00469-00419.

16. Tu V, Tomita T, Sugi T, Mayoral J, Han B, Yakubu R R, Williams T, Horta A, Ma Y, Weiss L M. The Toxoplasma gondii Cyst Wall Interactome [J]. mBio, 2020, 11(1): e02699-02619.

17. Pan G, Bao J, Ma Z, Song Y, Han B, Ran M, Li C, Zhou Z. Invertebrate host responses to microsporidia infections [J]. Developmental & Comparative Immunology, 2018, 83(104-113).

18. Sugi T, Ma Y F, Tomita T, Murakoshi F, Eaton M S, Yakubu R, Han B, Tu V, Kato K, Kawazu S-I, Gupta N, Suvorova E S, White M W, Kim K, Weiss L M. Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development [J]. mBio, 2016, 7(3): e00755-00716.

19. Ma Z, Li C, Pan G, Li Z, Han B, Xu J, Lan X, Chen J, Yang D, Chen Q, Sang Q, Ji X, Li T, Long M, Zhou Z. Genome-Wide Transcriptional Response of Silkworm (Bombyx mori) to Infection by the Microsporidian Nosema bombycis [J]. PLoS One, 2013, 8(12): e84137.

联系方式：

地址：济南市文化西路44号山东大学病原生物学系

电话：0531-88382042

E-mail: bing.han@sdu.edu.cn