
丛华,女,博士,1972年2月7日生人,山东大学基础医学院病原生物系教授
教育及工作简历
1989/9 - 1992/7 山东医科大学,卫生检验
1996/9 - 1999/7 山东医科大学,寄生虫学,硕士
2003/9 - 2006/7 山东大学,病原生物学, 博士
2009/4 - 2010/5 美国芝加哥大学,博士后
2012/01- 2014/12山东大学公共卫生学院,在职博士后
1992/7 - 1996/8 山东医科大学医学院微生物与免疫教研室,助教
2000/7 - 2005/8 山东大学医学院寄生虫教研室,讲师
2005/9 - 2015/8 山东大学医学院寄生虫教研室,副教授
2017/04-2018/05 美国芝加哥大学访问学者
2015/9 -至今 山东大学医学院寄生虫教研室,教授
主要研究方向
1、寄生虫与宿主的相互作用机制。从寄生虫与宿主两方面探讨寄生虫的致病机制。
2、寄生虫病的防治策略。寄生虫疫苗及药物研究。
近年来主持的课题
1. 山东省自然科学基金(ZR2021MH144) lncRNA11496靶向Mef2c调节神经突触在弓形虫
感染引起宿主精神行为异常中的作用及调控机制研究 2022/1-2024/12
2. 山东省自然科学基金(ZR2017MH043) miR132在弓形虫感染引起宿主精神行为异常的分子
机制及干预策略,2017/8——2020/6
3. 山东省重点研发项目(批准号:2016GSF201201),基于优势抗原多肽的弓形虫壳聚糖纳
米缓释疫苗的研究2016/10-2018/12
4. 国家自然科学基金面上项目(批准号:81171604),弓形虫HLA限制性表位疫苗及免疫
机制的实验研究,2012/01-2015/12
5. 国家自然科学基金青年项目(批准号:30700693)弓形虫profilin蛋白激活宿主TLR11
受体诱导信号传导的分子机制研究,2008.01-2010.12
6. 山东省中青年科学家奖励基金(批准号:2007BS03036),弓形虫核酸疫苗粘膜免疫的实
验研究,2007.12-2010.12
发表论文:
1.Wang Y, Han R, Xu Z, Sun X, Zhou C, Han B, He S*, Cong H*. Upregulation of ln cRNA147410.3 in the Brain of Mice With Chronic Toxoplasma Infection Promoted Micro glia Apoptosis by Regulating Hoxb3. Front Cell Neurosci. 2021 May 18;15:648047.
2.Sun X, Wang T, Wang Y, Ai K, Pan G, Li Y, Zhou C, He S and Cong H*. Downregulation of lncRNA-11496 in the Brain Contributes to Microglia Apoptosis via Regulation of Mef2c in Chronic T. gondii Infection Mice. Front. Mol. Neurosci. 2020;13:77.
3. Guo J, Zhou A, Sun X, Sha W, Ai K, Pan G, Zhou C, Zhou H, Cong H*, He S*.
Immunogenicity of a virus-like-particle vaccine containing multiple antigenic epitopes of Toxoplasma gondii against acute and chronic toxoplasmosis in mice. Front Immunol. 2019; 10:592.
4. Wang T#, Sun X#, Qin W, Zhang X, Wu L, Li Y, Zhou C, Zhou H, He S, Cong H*. From inflammatory reactions to neurotransmitter changes: Implications for understanding the neurobehavioral changes in mice chronically infected with Toxoplasma gondii. Behaviour Brain Res. 2019;359:737-748.
5. Guo J#, Sun X#, Yin H, Wang T, Li Y, Zhou C, Zhou H, He S*, Cong H*. Chitosan microsphere used as an effective system to deliver a linked antigenic peptides vaccine protect mice against acute and chronic Toxoplasmosis. Front Cell Infect Microbiol. 2018; 8:163.
6. Wang T#, Yin H#, Li Y#, Zhao L, Sun X, Cong H*. Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes. Parasite. 2017; 24:12.
7. Yin H#, Zhao L#, Wang T, Zhou H, He S, Cong H*. A Toxoplasma gondii vaccine encoding multistage antigens in conjunction with ubiquitin confers protective immunity to BALB/c mice against parasite infection. Parasit Vectors. 2015;8(1):498.
8. Cong H*, Yuan Q, Zhao Q, Zhao L, Yin H, Zhou H, He S, Wang Z*. Comparative efficacy of a multi-epitope DNA vaccine via intranasal, peroral, and intramuscular delivery against lethal Toxoplasma gondii infection in mice. Parasit Vectors. 2014; 7: 145.
9. Zhao L, Zhang M, Cong H*.Advances in the study of HLA-restricted epitope vaccines. Human Vaccines & Immunotherapeutics. 2014; 1:2566-77.
10. Zhang M, Zhao L, Song J, Li Y, Zhao Q, He S, Cong H*. DNA vaccine encoding the Toxoplasma gondii bradyzoite-specific surface antigens SAG2CDX protect BALB/c mice against type II parasite infection. Vaccine 2013; 31(41): 4536-40.
11. Cong H*, Zhang M, Xin Q, Wang Z, Li Y, Zhao Q, Zhou H, He S. Compound DNA vaccine encoding SAG1/SAG3 with A2/B subunit of cholera toxin as a genetic adjuvant protects BALB/c mice against Toxoplasma gondii. Parasit Vectors. 2013; 13; 6:63.
12. Cong H, Mui EJ, Witola WH, et al.Toxoplasma gondii HLA-B*0702-restricted GRA720-28 peptide with adjuvants and a universal helper T cell epitope elicits CD8+ T cells producing interferon-γ and reduces parasite burden in HLA-B* 0702 mice. Human immunology. 2012;73(1):1-10.
13. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R*. Towards an immunosense vaccine to prevent toxoplasmosis: protectiveToxoplasma gondiiepitopes restricted by HLA-A*0201.Vaccine. 2011;29(4):754-62.
14. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R*. Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective againstToxoplasma gondii.Immunome Res. 2010;6:12.
15. Cong H,Gu QM*,Yin HE,Wang JW,ZhaoQL,Zhou HY,Li Y,Zhang JQ. Multi-epitope DNA vaccine linked to the A2/B subunit of cholera toxin protect mice against Toxoplasma gondii.Vaccine. 2008;26(31):3913-21.
16. Cong H, Gu QM, Jiang Y, He SY, Zhou HY, Yang TT, Li Y, Zhao QL.Oral immunization with a live recombinant attenuated Salmonella typhimurium protects mice againstToxoplasma gondii.Parasite Immunol. 2005;27(1-2):29-35.
授权发明专利:
1. lncRNA11496在诊治弓形虫病中的应用 2019.4.15 中国 CN201910299793.4
2.一种弓形虫GRA10复合表位肽及其制备的疫苗 2018.7.03 中国 CN201510563797.0
3. 一种用于预防弓形虫病的多价腺病毒疫苗 2017.1.11 中国CN201410345709.5
4. 基于弓形虫缓殖子抗原的CD8+T细胞优势表位 2016.9.4 中国 CN201310204200.4
5. 用于预防人或动物慢性弓形虫病的DNA疫苗 2016.8.21 中国 CN201310201888.0
获得学术奖励:
丛华,何深一,周怀瑜,赵群力,赵玲潇 弓形虫多价和多表位核酸疫苗的实验研究,山东省教育厅,2014,山东省高等学校优秀科研成果奖,一等奖。
教材编书:
1.感染与免疫 副主编 山东大学出版社
2.医学寄生虫学 参编 中国医药科技出版社 “十三五”规划教材
3.寄生虫学与寄生虫病简史 副主编 全国高等医药院校规划教材
4.医学昆虫学 参编 人民军医出版社
5.人体寄生虫学实验技术 参编 人民卫生出版社
联系方式:
电话:0531-88382042
Email:conghua@sdu.edu.cn