1、基本信息

李艳，生物学博士学位，博士研究生学历，山东大学副教授。

2、研究领域与方向

1) 免疫负调分子调控细胞代谢影响免疫应答。

2) 肠道菌群与代谢性疾病机制的研究。

3) 细菌耐药性以及抗药性机制研究。

3、承担课题

1) D-甘露糖调控PPARγ-TPH2轴促进5-HT合成发挥抗抑郁作用及机制，国家自然科学基金青年基金，30万，主持

2) 尿路慢性感染中大肠杆菌耐药的分子机制研究，山东省自然科学基金，8万，主持并完成

3) 转录激活因子XYR1激活模式分子机制的研究，山东大学人才引进与培养基金，10万，主持并完成

4) PDCD4作为抑郁症和阿尔兹海默症（AD）药物研发，山东省重点研发计划，500万，参与

5) 共建“山东大学-诺亚创生生物研究院”协议书，1000万， 参与

4、主要研究论文

1) Li, W., Li, Y., Guan, Y., Du, Y., Zhao, M., Chen, X., Zhu, F., Guo, C., Jia, Y., Li, Yuan, Yan Li^*, Lining Zhang^*. (2021). TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis. Autophagy 17, 1410-1425.

2) Chen, X., Guan, Y., Zhang, Y., Jia, Y., Li, W., Guo, C., Li, Y., Wang, X., Shi, Y., Wang, Q., Faliang Zhu^*, Yan Li^*, Lining Zhang^* (2021). Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation. Cell Death Differ 28, 1237-1250.

3) Li, Yan^*, Liu, B., Guo, J., Cong, H., He, S., Zhou, H., Zhu, F., Wang, Q., and Zhang, L. (2019). L-Tryptophan represses persister formation via inhibiting bacterial motility and promoting antibiotics absorption. Future Microbiol 14, 757-771.

4) Wang, T^#., Yin, H. ^#, Li, Y. ^#, Zhao, L., Sun, X., and Cong, H. (2017). Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes. Parasite 24, 12.

5) Li Yan, Chen G, and Liu W. Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p. Mol Microbiol. 2010;78(2):414-28.

6) Li Yan, Chen G, and Liu W. Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1. Curr Microbiol. 2010;61(3):210-6.

7) Yu ShanShan^#, Li Yan^#, Chen Guan-Jun, Liu Wei-Feng Characterization of Aggregation-induced Toxicity by α-synuclein in Yeast. Microbiology. 2008, 35 (02): 249-255.

5、联系方式

山东大学基础医学院，济南市文化西路44号76信箱，邮编250012

办公电话：0531-88382042

E-mail: liyan2015@sdu.edu.cn