刘瑞康

刘瑞康，理学博士，山东大学基础医学院研究员，硕士生导师；山东省泰山学者青年专家；山东省优秀青年基金（海外）获得者。长期从事痘病毒的基础及应用基础研究，相关成果发表于PNAS、Cell Reports、mBio、PLOS Pathogens、Journal of Virology、Retrovirology以及Virology等期刊。

联系方式：邮箱：ruikangliu@email.sdu.edu.cn

研究方向：

痘病毒的分子病毒学。主要研究（1）痘病毒的复制机制、固有免疫逃逸机制，揭示猴痘病毒等痘病毒的致病机理；（2）以痘病毒为载体开发针对传染性疾病、重大生理病理疾病的治疗手段。

学术/社会兼职：

美国病毒学会会员

国际病毒学期刊Journal of Medical Virology审稿人

获奖荣誉：

山东省泰山学者青年专家(2023)

山东省优秀青年基金（海外）获得者(2022)

美国病毒学会（ASV）第38届年会博士后旅行奖(2019)

美国病毒学会（ASV）第35届年会博士后旅行奖(2016)

代表作文章：

第一作者论文（#共同第一作者）：

1. Ruikang Liu^#, Jeffrey L. Americo^#, Patricia L. Earl^#, Jack Villani, Catherine A. Cotter, Bernard Moss. Interferon a/β decoy receptor encoded by a variant in the Dryvax smallpox vaccine contributes to virulence and correlates with severe vaccine side effects. mBio. 2022; 13 (1): e00102-22 (Top Papers of the Year Submitted by American Academy of Microbiology Fellows)

2. Ruikang Liu^#, Jeffrey L. Americo^#, Catherine A. Cotter, Patricia L. Earl, Noam Erez, Chen Peng and Bernard Moss. One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection. PNAS. 2021; 118 (12): e2026785118

3. Ruikang Liu, Lisa R. Olano, Yeva Mirzakhanyan, Paul Gershon, and Bernard Moss. Vaccinia virus ankyrin-repeat/F-box protein targets interferon-induced IFITs for degradation. Cell Reports. 2019; 29 (4): 816–828

4. Ruikang Liu, Jorge D. Mendez-Rios, Chen Peng, Wei Xiao, Andrea S. Weisberg, Linda S. Wyatt and Bernard Moss. SPI-1 is a missing host-range factor required for replication of the attenuated modified vaccinia Ankara (MVA) vaccine vector in human cells. PLOS Pathogens. 2019; 15 (5): e1007710 (Featured research article)

5. Ruikang Liu and Bernard Moss. Vaccinia virus C9 ankyrin repeat/F-Box protein is a newly identified antagonist of the type I interferon-induced antiviral state. Journal of Virology. 2018; 92 (9): e00053-18

6. Ruikang Liu and Bernard Moss. Opposing roles of double-stranded RNA effector pathways and viral defense proteins revealed with CRISPR-Cas9 knockout cell lines and vaccinia virus mutants. Journal of Virology. 2016; 90 (17): 7864–7879

7. Ruikang Liu^#, Yongquan Lin^#, Rui Jia, Yunqi Geng, Chen Liang, Juan Tan, Wentao Qiao. HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1. Retrovirology. 2014; 11: 45

8. Ruikang Liu^#, Juan Tan^#, Yongquan Lin, Rui Jia, Wei Yang, Chen Liang, Yunqi Geng, Wentao Qiao. HIV-1 Vpr activates both canonical and noncanonical NF-κB pathway by enhancing the phosphorylation of IKKα/β. Virology. 2013; 439 (1): 47–56

参与作者论文：

1. Jeffrey Americo, Catherine Cotter, Patricia Earl, Ruikang Liu, Bernard Moss. Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection. PNAS. 2022; 119(24): e2202069119

2. Zhibin Liang, Ruikang Liu, Hui Zhang, Suzhen Zhang, Xiaomei Hu, Juan Tan, Chen Liang, Wentao Qiao. GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. Virology. 2016; 493: 1–11

3. Zhibin Liang, Ruikang Liu, Yongquan Lin, Chen Liang, Juan Tan, Wentao Qiao. HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest. Virologica Sinica. 2015; 30 (6): 441–448

4. Shin-Wu Liu, George C. Katsafanas, Ruikang Liu, Linda S. Wyatt, and Bernard Moss. Poxvirus decapping enzymes enhance virulence by preventing the accumulation of dsRNA and the induction of innate antiviral responses. Cell Host & Microbe. 2015; 17 (3): 320–331

5. Xiaomei Hu, Wei Yang, Ruikang Liu, Yunqi Geng, Wentao Qiao, Juan Tan. N-Myc interactor inhibits prototype foamy virus by sequestering viral Tas protein in the cytoplasm. Journal of Virology. 2014; 88 (12): 7036–7044

6. Wei Yang, Juan Tan, Ruikang Liu, Xiaoxu Cui, Qinglin Ma, Yunqi Geng, Wentao Qiao. Interferon-gamma upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1. PLOS ONE. 2012; 7 (12): e50932

7. Fengwen Xu, Juan Tan, Ruikang Liu, Dan Xu, Yue Li, Yunqi Geng, Chen Liang, Wentao Qiao. Tetherin inhibits prototypic foamy virus release. Virology Journal. 2011; 8: 198

承担课题：

2023.04  山东省泰山学者青年专家，75万元

2022.12  山东省优秀青年科学基金项目（海外），60万元

2022.12  国家自然科学基金猴痘专项项目，65万元

2022.09  国家自然科学基金青年项目，30万元