
陈恬
陈恬,理学博士,山东大学基础医学院副教授,硕士生导师。长期从事真菌感染与固有免疫调控的基础及应用基础研究,相关成果发表于Immunity, mBio, PLoS Genetics等期刊。研究成果被Nat Rev Immunol, Trends Microbiol等高水平期刊选为研究亮点并进行专评。主持国家自然科学基金青年项目,中国博士后科学基金面上项目,山东大学齐鲁医学院培育项目,授权国家发明专利1件。获山东大学青年学者未来计划奖励。
招生方向:免疫学
联系方式:邮箱:chentian@sdu.edu.cn
学习经历:
2013.08 - 2019.08 美国田纳西大学, 病原微生物与免疫学, 博士
2009.09 - 2012.06 西南大学, 微生物学, 硕士
2005.09 - 2009.06 重庆师范大学, 生物技术, 学士
工作经历:
2024.09 - 至今 山东大学,基础医学院,副教授
2019.11 - 2024.08 山东大学, 基础医学院, 助理研究员
研究方向:
真菌感染和固有免疫调控
学术/社会兼职:
世界华人医师协会医学真菌专业委员会委员
Molecular Immunology等杂志审稿人
获奖荣誉:
山东大学青年学者未来计划
代表作文章:
1. Tian Chen; Yiting Feng; Wanwei Sun; Guimin Zhao; Han Wu; Xiaochen Cheng; Fabao Zhao; Lei Zhang; Yi Zheng; Peng Zhan; Wei Zhao; Bingyu Liu; Chengjiang Gao ; The Nucleotide Receptor STING Translocates to the Phagosomes to Negatively Regulate Anti-fungal Immunity, Immunity, 2023, 56: 1727-1742
2. Tian Chen; Andrew Wagner; Robert Tams; James Eyer; Sarah Kauffman; Eric Gann; Elias Fernandez; Todd Reynolds ; Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway, mBio, 2019, 10: e01767-19
3. Tian Chen; Joseph Jackson; Robert Tams; Sarah Davis; Timothy Sparer; Todd Reynolds ; Exposure of Candida albicans β (1,3)-Glucan is Promoted by Activation of the Cek1 Pathway, PLoS Genetics, 2019, 15: e1007892
4. Tian Chen; Chengjiang Gao ; Innate Immune Signal Transduction Pathways to Fungal Infection: Components and Regulation, Cell Insight, 2024, 3: 100154
5. Tian Chen#; Andrew Wagner#; Todd Reynolds ; When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure in Candida albicans, Frontiers in Fungal Biology, 2022, 3: 842501
6. Yuanbo Zhong; Tian Chen*; Xu Wang*; Repairing Creep-Resistant and Kinetically Inert Hydrogels via Yeast Activity-Regulated Energy Dissipation, ACS Applied Bio Materials, 2020, 3: 4507-4513
7. Tian Chen; Quanju Zhao; Wu Li; Jianping Xie ; Mycobacterium tuberculosis PE_PGRS17 Promotes the Death of Host Cell and Cytokines Secretion via Erk Kinase Accompanying with Enhanced Survival of Recombinant Mycobacterium smegmatis, Journal of Interferon and Cytokine Research , 2013, 33: 452-458
8. Tian Chen; Liming He; Wanyan Deng; Jianping Xie ; The Mycobacterium DosR Regulon Structure and Diversity Revealed by Comparative Genomic Analysis, Journal of Cellular Biochemistry, 2013, 114: 1-6
9. Tian Chen; Jianping Xie ; Roles of PE_PGRS Family in Mycobacterium tuberculosis Pathogenesis and Novel Measures against Tuberculosis, Microbial Pathogenesis, 2010, 49: 311-314.
承担课题:
1. 去泛素化酶USP5调控NLRP3炎症小体活化的分子机制研究,国家自然科学基金青年项目,2021.01-2023.12,24万,负责人;
2. 白色念珠菌MAPK信号通路调控宿主免疫识别的机制研究,中国博士后基金,2020.07-2023.12,8万,负责人;
3. 山东大学青年学者未来计划,校级,2022.01-2026.12,50万,负责人;
4. 齐鲁医学院高层次人才培育项目,校级,2023.08-2024.08,12万,负责人;
5. 核糖体相关质量控制体系调控抗病毒天然免疫的分子机制研究,国家自然科学基金重点项目,2023.01-2026.12,300万,课题骨干。