孙允东

基本情况：

孙允东，山东大学病原微生物学教授，博士生导师，美国密歇根大学访问学者。《Microbiology Spectrum》、《Antimicrob Agents Chemother》与《Helicobacter》等SCI杂志审稿人。山东省微生物与免疫学会会员。主要从事幽门螺杆耐药机制与分子诊断研究，消化道菌群与健康以及消化道菌群与疾病筛查，在Gastroenterology，Antimicrob Agents Chemother等杂志发表论文十余篇。获批国家自然基金5项，参与山东省重大创新工程项目。获批专利两项。

联系方式：QQ328366628；

      syd@sdu.edu.cn

主持课题：

(1)  抗生素通过ROS抑制mutS、mutY表达介导幽门螺杆菌耐药机制研究（82172313），国家自然科学基金委面上项目, 55万元, 2022-2025。

(2)  抗幽门螺杆菌试剂盒的研发（与江苏绿叶诊断技术有限公司横向项目），100万元，2023-2026。

(3)  SpoT(ppGpp)调控幽门螺杆菌适应抗生素压力分子机制研究（81471991），国家自然基金面上项目，72万，2015-2018。

(4)  压力加重幽门螺杆菌胃炎分子机制研究（81671978），国家自然基金面上项目，70万，2017-2020。

(5)  幽门螺杆菌SpoT基因适应INF-γ表达调控机制研究（81071313），国家自然基金面上项目，32万，2011-2013。

(6)  SpoT调控幽门螺旋杆菌氧应激严谨应答分子机制研究(30800037)，国家自然基金青年基金，20万，2009-2011。

发表论文（*通讯作者）

1、Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY*. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology. 144(7):1478-87, 1487.e1-8; 2013 Jun.

2、 Xue J, Li S, Wang L, Zhao Y, Zhang L, Zheng Y, Zhang W, Chen Z, Jiang T, Sun Y*. Enhanced fatty acid biosynthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0085024. doi: 10.1128/aac.00850-24.

3、 Xue J, Li S, Wang L, Zhao Y, Zhang L, Zheng Y, Zhang W, Chen Z, Jiang T, Sun Y*. Enhanced fatty acid biosynthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0085024. doi: 10.1128/aac.00850-24.

4、 Wang D, Feng Y, Yang M, Sun H, Zhang Q, Wang R, Tong S, Su R, Jin Y, Wang Y, Lu Z, Han L, Sun Y*. Variations in the oral microbiome and metabolome of methamphetamine users. mSystems. 2024 Jan 23;9(1):e0099123. doi: 10.1128/msystems.00991-23.

5、 Wang L, Yu Y, Tao Y, Zhao M, Zhang L, Xue J, Zhao Y, Zhan P, Sun Y*. The Quinone-Derived Small Molecule M5N32 Is an Effective Anti-Helicobacter pylori Agent Both In Vivo and In Vitro. J Infect Dis. 2022 Dec 8;226(Suppl 5):S493-S502. doi: 10.1093/infdis/jiac401. PMID: 36478249.

6、 Li, Y., Li, W., Wang, X., Ding, C., Liu, J., Li, Y., Li, W., & Sun Y*. (2020). High-Salt Diet-Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet. Molecular nutrition & food research, 64(8), e1900965.

7、 Zhao, Y., Cai, Y., Chen, Z., Li, H., Xu, Z., Li, W., Jia, J., & Sun Y*. (2021). SpoT-mediated NapA upregulation promotes oxidative stress induced Helicobacter pylori biofilm formation and confers multidrug resistance. Antimicrobial agents and chemotherapy, AAC.00152-21.

8、 Cai, Y., Wang, C., Chen, Z., Xu, Z., Li, H., Li, W., & Sun, Y*. (2020). Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation in Helicobacter pylori by enhancing drug efflux. Helicobacter, e12715.

9、 Ge, X., Cai, Y., Chen, Z., Gao, S., Geng, X., Li, Y., Li, Y., Jia, J., & Sun, Y*. (2018). Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (gluP). Antimicrobialagents and chemotherapy, 62(11), e00957-18.

10、 Geng, X., Li, W., Chen, Z., Gao, S., Hong, W., Ge, X., Hou, G., Hu, Z., Zhou, Y., Zeng, B., Li, W., Jia, J., &Sun, Y*. (2017). The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. Antimicrobial agents and chemotherapy, 61(5), e02011-16